CCMB

CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research

The Innovation Engine of India

Ministry of Science & Technology, Govt. of India

The People

B Kiran Kumar

B Kiran Kumar

Senior Scientist
5547
bokarakiran@ccmb.res.in

Research Interests:

The specific microenvironments regulating stem cells, commonly referred to as niches, comprise multiple cell populations whose precise contributions are under active current exploration. Understanding the cross-talk between stem cells and their niche components is essential for the development of therapies against disorders in which stem cells function is altered.
Currently we are focusing on investigating neuronal injury and its repair mechanisms under various conditions. We use 2D & 3D cell culture platforms and animal model systems. Advanced microscopy and Molecular and cell biology techniques will be used to understand these processes.

Selected Publications:

Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions Journal of Respiratory Research, 2021, 6; 22(1): 99.

Long term observation of ocular surface alkali burn in rabbit models: Quantitative analysis of corneal haze, vascularity and self-recovery, Experimental Eye Research, 2021 2;205:108526.

Prevention of corneal myofibroblastic differentiation in vitro using biomimetic ECM hydrogel for corneal tissue regeneration. ACS Applied Biomaterials, 2021, 4, 1, 533–544 HspB5 protects Mouse Neural Stem/Progenitor Cells from Paraquat Toxicity, American Journal of Stem Cells, Dec 25;9(5):68-77. eCollection 2020.

Generation of iPSC from fetal fibroblast cells obtained from an abortus with type-I tri-allelic variants. Stem Cell Research. Volume 48 2020, 101963.

Transfection of arginine decarboxylase gene increases the neuronal differentiation of neural progenitor cells. Stem Cell Research. 17 256–265, 2016.

Education & Experience

P.G:

Andhra University ; Zoology Spl: Animal Physiology ; 2001

Ph.D:

Andhra University ; 2008 ;

Post.Doc:

Yonsei University College of Medicine, Department of Neuroscience, Seoul, South Korea ; 2008-2013 ;

Team Members

team-members-pic
Khyathi Ratna
Khyathi Ratna

Project Associate-I

Project Associate-I

Yogesh Sardana
Yogesh Sardana

Project Associate-I

Project Associate-I

Alna K M
Alna K M

Project Associate-I

Project Associate-I

Renuga Devi M
Renuga Devi M

Project Associate - I

Project Associate - I

K Sreenivasan
K Sreenivasan

Project Associate-I

Project Associate-I

Prashanth N
Prashanth N

Project Associate - I

Project Associate - I

Nandhakumaar R
Nandhakumaar R

Project Associate-I

Project Associate-I

Publications

Title

Journal

Year

Exploration of Multi-layered Nanofiber Adjuvant Implants of Doxorubicin and Resveratrol to Prevent Post-Surgery Tumor Recurrence and Invasion,
Journal of Drug Delivery Science and Technology
2024
Developing a model for aqueous deficient dry eye secondary to periglandular cicatrizing conjunctivitis
Experimental Eye Research
2024
Revisiting rabbit models for keratoconus: A long-term study on collagenase-induced disease progression
Experimental Eye Research
2024
Development and validation of a reliable rabbit model of limbal stem cell deficiency by mechanical debridement using an ophthalmic burr
Experimental Eye Research
2023
Human cornea-derived extracellular matrix hydrogel for prevention of post-traumatic corneal scarring: A translational approach
Acta Biomaterialia
2023
Discovery of SARS-CoV-2 Inhibitors Featuring Novel Histidine α-Nitrile Motif
Chemistry and Biodiversity
2023
A review of rabbit models of meibomian gland dysfunction and scope for translational research
Indian Journal of Opthalmology
2023
Benzalkonium chloride-induced dry eye disease animal models: Current understanding and potential for translational researc
Indian Journal of Opthalmology
2023
Repeatability of Non-invasive Tear Film Evaluation in Healthy Rabbit Eyes
Experimental Eye Research
2023
Assessment of epithelial restoration using limbal allograft transplantation in rabbit model with persistent corneal epithelial defect
Investigative Ophthalmology & Visual Science
2022
BIOPRINTING OF CORNEAL STROMA AND EPITHELIUM TISSUE WITH BIOMIMETIC HYDROGEL SUPPORTING SCARLESS CORNEAL TISSUE REGENERATION
TISSUE ENGINEERING PART A
2022
A biomimetic hydrogel-based therapeutic approach for preventing corneal scarring
Investigative Ophthalmology & Visual Science
2022
Covid -19 repellent cloth
Frontiers in Chemical. Engineering, Sec. Surface and Interface Engineering
2022
Theafavin 3-gallate inhibits the main protease (Mpro) of SARS-CoV-2 and reduces its count in vitro
Scientific Reports
2022
Anti-SARS-CoV-2 potential of Cissampelos pareira L. identified by connectivity map-based analysis and in vitro studies
BMC Complimentary Medicine and Therapies
2022
Neural Stem Cells From Bench to Bedside
Handbook of Stem Cell Therapy
2022
Gramicidin S and melittin: potential anti-viral therapeutic peptides to treat SARS-CoV-2 infection
Scientific Reports
2022
Antimicrobial silver nanoparticle-photodeposited fabrics for SARS-CoV-2 destruction
Colloid and Interface Science Communications
2021
Prevention of corneal myofibroblastic differentiation in vitro using biomimetic ECM hydrogel for corneal tissue regeneration
ACS Applied Biomaterials
2021
Long term observation of ocular surface alkali burn in rabbit models: Quantitative analysis of corneal haze, vascularity and self-recovery
Experimental Eye Research
2021
Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions
Journal of Respiratory Research
2021
Design and synthesis of new thiazoles by microwave-assisted method: Evaluation as an anti-breast cancer agents and molecular docking studies
Synthetic Communications
2020
Generation of iPSC from fetal fibroblast cells obtained from an abortus with type-I tri-allelic variants
Stem Cell Research
2020
HspB5 protects Mouse Neural Stem/Progenitor Cells from Paraquat Toxicity,
American Journal of Stem Cells
2020
Inflammation, vascularization and goblet cell differences in LSCD: Validating animal models of corneal alkali burns
Experimental Eye Research
2019
Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors
Bioorganic Chemistry
2019
Gene delivery approaches for mesenchymal stem cell therapy: Strategies to increase efficiency and specificity
Stem Cell Reviews and Reports
2017
Anticancer activity of large metalla assemblies built from half sandwich complexes
CrystEngComm
2016
Transfection of arginine decarboxylase gene increases the neuronal differentiation of neural progenitor cells
Stem Cell Research.
2016
Agmatine Improves Cognitive Dysfunction and Prevents Cell Death in a Streptozotocin-Induced Alzheimer Rat Model
Yonsei Medical Journal
2014
Modulation of stem cell differentiation by the influence of nano-bio-materials/carriers
Current Stem Cell Research and Therapy
2014
Foil assisted replica molding for fabrication of microfluidic devices and their application in vitro
Lab on a Chip
2014
The multifaceted effects of agmatine on functional recovery after contusion spinal cord injury through modulations of BMP-2, 4, 7 expressions in neurons, oligodendrocytes and astrocytes
PLoS ONE
2013
Agmatine promotes the migration of murine brain endothelial cells via multiple signaling pathways
Life sciences
2013
The Effect of Agmatine on Expression of IL-1β and TLX Which Promotes Neuronal Differentiation in Lipopolysaccharide-Treated Neural Progenitors
Experimental Neurobiology
2013
Stem cells and stress injury: Role of arginine decarboxylase(Book Chapter)
Stem Cells and Cancer Stem Cells
2012
Genetically modified stem cells and their applications in central nervous system injury models.
Vascular Neurology
2012
Carbon nanotubes impregnated with subventricular zone neural progenitor cells promotes recovery from ischemic injury
International Journal of Nanomedicine
2012
Biocompatability of carbon nanotubes with stem cells to treat CNS injuries
Anatomy and Cell Biology.
2012
Agmatine enhances neurogenesis by increasing ERK1/2 Expression, and suppresses astrogenesis by decreasing BMP2 and BMP4 expression in SVZ Neural Stem Cells
Life sciences
2011
Retroviral Expression of Arginine Decarboxylase Rescued Mouse Cortical Neural Stem Cells against H2O2 Injury
Stem Cell and Development
2011
The expression of human papillomavirus type 16 (HPV 16 E7) induces cell cycle arrest and apoptosis in radiation and hypoxia resistant glioblastoma cell line (U87 MG).
Molecular Medicine Reports
2011
Recombinant hexahistidine arginine decarboxylase (hisADC) induced endogenous agmatine synthesis during stress
Molecular and Cellular Biochemistry
2010
Agmatine and Angiogenesis in Cerebral Ischemia: Therapeutic Approaches.
Vascular Neurology
2010
Influence of lead on glutathione system in different regions of rat brain
Journal of Applied toxicology
2009
Lead-Induced alteration of apoptotic proteins in different regions of adult rat brain.
Toxicology letters
2009
Lead-induced increase in antioxidant enzymes and lipid peroxidation products in developing rat brain
Biometals
2008
Region specific increase in the antioxidant enzymes and lipid peroxidation products in the brain of rats exposed to lead
Free Radical Research
2006
In vitro effect of Lead on Na+ K+ ATPase activity in Different Regions of Adult Rat Brain
Drug and Chemical Toxicology
2003
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