CCMB

CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research

The Innovation Engine of India

Ministry of Science & Technology, Govt. of India

The People

N Nagesh

N Nagesh

Chief Scientist
5563
nagesh@ccmb.res.in

Research Interests:

  • Biochemical and Biophysical studies involving the interaction of different forms of DNA (double, triple and quadruplex forms) with small molecules, metals and macromolecules.
  • Studies to understand the mechanism of modified, novel organic and inorganic complexes in enhancing anti-cancer/pro-apoptotic activity among cancer cells and reduce cancer cell proliferation both under in vitro and in vivo conditions,
  • Research activity that brings the industry and academics together.

Selected Publications:

Magnetic bead-amplified voltammetric detection for carbohydrate antigen 125 with enzyme labels using aptamer-antigen-antibody sandwiched assay. (2020) Mohanraj Sadasivam, Arunkumar Sakthivel ??, ?Narayana Nagesh, Shekhar Hansda, Murugan Veerapandian, Subbiah Alwarappan, Pandiaraj Manickam. Sensors & Actuators: B. Chemical, 312, 127985-127991. https://doi.org/10.1016/j.snb.2020.127985. (IF 6.3).

Design,synthesis and biological evaluation of new ?-carboline bisindole compounds as DNA binding, photocleavage agents and topoisomerase inhibitors. (2018) Jeshma Kovvuri , Burri Nagaraju, V. Lakshma Nayak, Ravi kumar Akunuri, M.P.Narasimha Rao, Ayyappan Ajitha, Narayana Nagesh*, Ahmed Kamal*. European Journal of MedicinalChemistry. Volume 143, 1563-1577. (IF- 4.8).

Telomerase inhibition and human telomeric G-quadruplex DNA stabilization by a ?-carboline–benzimidazole derivative at low concentration.(2017) Kranthikumar Yadav, Penchala Narasimha Rao Meka, Sudeshna Sadhu, Sravanthi Devi Guggilapu, Jeshma Kovvuri, Ahmed Kamal, Ragampeta Srinivas, Panuganti Devayani, Bathini Nagendra Babu, and Narayana Nagesh*. ACS Biochemistry, 56 (33), 4392–4404. DOI: 10.1021/acs.biochem.7b00008. (IF-2.9).

Synthesis, DNA binding affinity and anticancer activity of novel 4Hbenzo[g][1,2,3]triazolo [5,1-c][1,4]oxazocines. (2016) K. N. Visweswara Sastry, Sunitha Routhu, Soma Gupta Datta, Narayana Nagesh,* Bathini Nagendra Babu, Jagadeesh Babu Nanubolu, C. Ganesh Kumar, Ram Awatar Maurya* and Ahmed Kamal*. Organic Biomolecular Chemistry, 14, 9294–9305. (I.F- 3.6).

Sugar-boronate ester scaffold tethered pyridyl -imine palladium(II) complexes:Synthesis and their in vitro anticancer evaluation. (2015) Eda Rami Reddy, Rajiv Trivedi*, Akella Venkata Subrahmanya Sarma, Balasubramanian Sridhar,Hasitha Shilpa Anantharaju,Dharmarajan Sriram, Perumal Yogeeswari, Narayana Nagesh* Dalton Transactions, 44,17600-17616. (IF- 4.1).

A dihydroindolizino indole derivative selectively stabilizes G quadruplex DNA and down regulates c-MYC expression in human cancer cells. (2015) Narayana Nagesh*, G. Raju, R. Srinivas, P. Ramesh, M. Damoder Reddy, Ch. Raji Reddy. Biochimica et Biophysica Acta (BBA)-General Subjects, 1850(1), 129-140. (IF-4.4).

Patents:

Title of the Patent: Synthesis of N-((1-pheny1-9H-pyrido[3,4 b]indo1-3- y1) methy1) cinnamamides as potential Anticancer Agents. File Reference No: PT-649. CSIR Ref No.: 0272NF2015. Inventors: Ahmed Kamal, Manda Sathish, Narayana Nagesh, Nagula Shankaraiah, Sabanis Chetan Dushantrao, Namballa Hari Krishna. Countries: India, US, UK, Germany, France. International Patent Classification: C07D 471/04(2006.01); A61K 31/437(2006.01). Title of the Patent: A process for preparing 2-pyrimidyl substituted-2,3-dihydro-1H naphtho[1,2-e][1,3]oxazines. Application No: 201921033132. Inventors: Rakhi Gajanan Gawali, Raghunath Bhikaji Bhosale, Sachin Pandurang Shirame, Narayana Nagesh. Countries: India.

Education & Experience

P.G:

Chemistry ; S. V. University, Tirupati ; 1987

Ph.D:

Studies on the Structure and Interaction of G-Quadruplex DNA with Metal Ions and Drugs ; S. V. University, Tirupati ; 2005

Post.Doc:

Studies on Bcl2 Quadruplex DNA interaction with Porphyrins ; With Prof. Edwin A Lewis, Department of Chemistry at North Arizona University, Flagstaff, Arizona, USA ; 2006 – 2007.

 

Experience:

About 31 years of experience in the fields of Biochemistry, Biophysics, Medicinal Chemistry, Bio-organic Chemistry.

Team Members

team-members-pic
Manoj Kumar Balyan
Manoj Kumar Balyan

Senior Scientist

Senior Scientist

Publications

Title

Journal

Year

Development of β-Carboline-Coumarin Based Hybrids as Potential Cytotoxic and Topoisomerase IIα Inhibitors
ChemistrySelect
2024
A Hydrogen Bonded Non-Porous Organic-Inorganic Framework for Measuring Cysteine in Blood Plasma and Endogenous Cancer Cell
Chemistry - A European Journal
2024
Synthesis and antibacterial evaluation of new naphthalimide-coumarin hybrids against multidrug-resistant S. aureus and M. tuberculosis.
Journal of Molecular Structure
2024
Benzimidazole derivatives as tubulin polymerization inhibitors: Design, synthesis and in vitro cytotoxicity studies
Biorganic Medicinal Chemistry Letters
2023
Synthesis and Biological Evaluation of 1-Phenyl-4,6-dihydrobenzo[b]pyrazolo[3,4-d] azepin-5(1H)-one/thiones as Anticancer Agents.
Bioorganic Chemistry
2023
Triazolo-linked benzimidazoles as tubulin polymerization inhibitors and DNA intercalators: Design, synthesis, cytotoxicity and docking studies
Archiv der Pharmazie
2023
Benzimidazole based bis-carboxamide derivatives as promising cytotoxic agents: Design, synthesis, in silico and tubulin polymerization inhibition.
Journal of Molecular Structure
2023
Synthesis and cytotoxicity evaluation of DNA-interactive β-carboline indolyl-3-glyoxamide derivatives: Topo-II inhibition and in silico modelling studies.
Bioorganic Chemistry
2023
1, 2, 3-Triazolo-2-Aryl-Linked Benzimidazole Derivatives as Tubulin Polymerization Inhibitors and DNA Intercalators: Design, Synthesis, Biological Evaluation and Docking Studies
SSRN Electronic Journal.
2022
A unique water soluble probe for measuring the cardiac marker homocysteine and its clinical validation
Chemical Communications
2022
Exploration of Mercaptoacetamide-linked Pyrimidine-1,3,4-Oxadiazole Derivatives as DNA Intercalative Topo II inhibitors: Cytotoxicity and Apoptosis Induction.
Bioorganic & Medicinal Chemistry Letters.,
2022
Towards the development of reagent-free and reusable electrochemical aptamer-based cortisol sensor.
Bioelectrochemistry
2022
Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors.
Bioroganic Chemistry
2022
Ready-to-Use Vertical Flow Paper Device for Instrument-free Room Temperature Reverse Transcription.
New Biotechnology.
2022
Design, Synthesis and Biological Evaluation of Hybrid C3-Quinazolinone linked β-carboline Conjugates as DNA Intercalative Topoisomerase I Inhibitors
JSM Clinical Pharmaceutics (Accepted)
2021
Benzimidazole-1,2,3-triazole hybrid molecules: synthesis and study of their interaction with G-quadruplex DNA
RSC Medicinal Chemistry
2021
Synthesis and biological evaluation of novel imidazo[1,2-a]pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding
Bioorganic and Medicinal Chemisry
2021
Targeting Tubulin Polymerization and DNA Binding of 4-Thiazolidinone -umbelliferone Hybrids: Synthesis and Cytotoxicity Evaluation.
New Journal of Chemistry
2021
Development of β-carboline -benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase II? inhibition and apoptosis induction
Bioorganic Chemistry, Vol. 106, 104481
2021
3-Functionalised Benzenesulphonamide based 1,3,4-oxadiazoles as Selective Carbonic Anhydrase XIII Inhibitors: Design, Synthesis and Biological Evaluation.
Bioorganic Medicinal Chemistry Letters., 37, 127856.
2021
Magnetic bead-amplified voltammetric detection for carbohydrate antigen 125 with enzyme labels using aptamer-antigen-antibody sandwiched assay.
Sensors & Actuators: B. Chemical. 312, 127985-127991.
2020
Amberlite IR-120H Catalyzed Synthesis of 1,3-Diphenylpyrazole-chromenoquinolin-6-one Compounds and Their Biological Evaluation.
American Journal of Medicinal Chemistry,2(1), 2-16.
2020
Design and Synthesis of β-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability.
Bioorganic Chemistry, 101, 103983.
2020
The β-carboline alkaloids in cancer therapy- recent advancements in this area. (Review Article)
IOSR Journal Of Pharmacy And Biological Sciences (IOSR-JPBS)
2020
Design and synthesis of substituted (1-(benzyl)-1H-1,2,3-triazol-4yl)(piperazin-1-yl)methanone conjugates: Study on their apoptosis inducing ability and tubulin polymerization inhibition.
RSC Medicinal Chemistry.
2020
Recent Insights into β-Carboline Alkaloids with Anticancer Potential.
Modern Approches in Drug Design. 3(1)
2020
A New Class of Naphthalimides derivatives: Design, synthesis, DNA-interaction and topoisomerase II inhibition studies.
Med. Chem. Commun., 10, 72 ?79.
2019
Synthesis and Biological Evaluation of Pyrazole Linked Benzothiazole-β-Naphthol Derivatives as Topoisomerase I Inhibitors with DNA Binding Ability.
Bioorganic and Medicinal Chemistry, 27, 708?720.
2019
Synthesis and in vitro cytotoxicity evaluation of β-carboline-combretastatin carboxamides as apoptosis inducing agents: DNA intercalation and topo- isomerase-II inhibition.
Bioorganic & Medicinal Chemistry, 27, 3285?3298.
2019
Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors.
Bioorganic Chemistry 93 (2019) 103317
2019
Design,synthesis and biological evaluation of new β-carboline-bisindole compounds as DNA binding, photocleavage agents and topoisomerase inhibitors.
European Journal of Medicinal Chemistry, 143,1563-1577.
2018
Synthesis of podophyllotoxinlinked β-carboline congeners as potential anticancer agents
European Journal of Medicinal Chemistry, 144,557-571.
2018
Iodine-mediated one-pot intramolecular decarboxylation domino reaction for accessing functionalized 2-(1,3,4-oxadiazol-2-yl)anilines with carbonic anhydrase inhibitory action
Journal Of Enzyme Inhibition And Medicinal Chemistry, 33(1),615-628.
2018
BODIPY-based Ir (III) rectangles containing bis-benzimidazole ligands with highly selective toxicity obtained through self-assembly.
Journal of Organometallic Chemistry, 868, 86-94.
2018
BODIPY-based Ru(II) and Ir(III) organometallic complexes of avobenzone, a sunscreen material: potent anticancer agents.
J Inorg. Biochem., Vol.189, 17-29.
2018
Synthesis of DNA interactive C3-trans-cinnamide linked β-carboline conjugates as potential cytotoxic and DNA topoisomerase I inhibitors
Bioorganic and Medicinal Chemistry, 26, 4916?4929
2018
Novel Amphiphillic G-quadruplex binding synthetic derivative of TMPyP4 and its effect on cancer cell proliferation and apoptosis induction.
ACS Biochemistry, 57 (46), 6514-6527.
2018
2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway.
Apoptosis, 22,118-134.
2017
Design, Synthesis, in vitro and in vivo Evaluation of (Z)-3,4,5-Trimethoxystyryl Benzenesulfonamides/Sulfonates as Highly Potent Tubulin Polymerization Inhibitors.
ChemMedChem., 12(9), 678?700.
2017
Forced degradation studies of lansoprazole using LC-ESI HRMS and 1H-NMR experiments: in vitrotoxicity evaluation of major degradation products.
Journal of Mass Spectrometry, 52(7), 459?471.
2017
An efficient one-pot approach for the regio and diastereoselective synthesis of trans-dihydrofuran derivatives: Cytotoxicity and DNA-binding studies.
Org. Biomol. Chem., 15, 6837-6853.
2017
Telomerase inhibition and human telomeric G-quadruplex DNA stabilization by a β-carboline βbenzimidazole derivative at low concentration.
ACS Biochemistry, 56 (33), 4392?4404.
2017
Design and synthesis of C3-tethered 1,2,3-triazolo-β-carboline derivatives: Anticancer activity, DNA-binding ability, viscosity and molecular modeling studies.
Bioorganic Chemistry, 64, 42-50.
2016
Identification and characte- rization of stressed degrada- tion products of rabeprazole using LC /ESI / MS /MS and 1H-NMR experiments: In vitrotoxicity evaluation of major degradation products
RSC Advances, 6, 10719-10735.
2016
Anticancer activity of large metalla-assemblies built from half-sandwich complexes.
CrystEngComm. DOI: 10.1039/C6CE00139D. 18, 4952-4957.
2016
Manganese-superoxide dismutase (Mn-SOD) overexpression is a common event in colorectal cancers with mitochondrial microsatellite instability.
Tumor Biology (DOI: 10.1007/s13277-016-4918-0)
2016
Association of mitochon- drial displacement loop polymorphisms with risk of colorectal cancer in south Indian population.
Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis, http://dx.doi.org/10.3109/24701394.2016.1160076.
2016
Benzo[b]furan derivatives induces apoptosis by targeting the PI3K/Akt/ mTOR signaling pathway in human breast cancer cells
Bioorganic Chemistry, 66, 124?131.
2016
Synthesis, DNA binding affinity and anticancer activity of novel 4H-benzo[g][1,2,3]triazolo[5,1-c][1,4]oxazocines.
Organic & Biomolecular Chemistry, Org. Biomol. Chem., 14, 9294?9305
2016
A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells.
Biochimica et Biophysica Acta (BBA) - General Subjects, 1850 (1), 129?140
2015
DNA-Binding Affinity and Anticancer Activity of β-Carboline-Chalcone Conjugates as Potential DNA Intercalators: Molecular Modeling and Synthesis.
Bioorganic Chemistry, 59, 130-139. doi: 10.1016/j.bioorg.2015.02.007
2015
Biological activities of pyrenyl-derived thiosemicarbazone half-sandwich complexes.
Journal of Organometallic Chemistry, 794, 104-114. doi:10.1016/j.jorganchem.2015.06.036.
2015
Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability.
Bioorganic Medicinal Chemistry, 23(17), 5511-5526.
2015
Sugar-boronate ester scaffold tethered pyridyl -imine palladium(II) complexes : Synthesis and their in vitro anticancer evaluation.
Dalton Transactions 44(40):17600-17616.
2015
Phenotypic Variations in the 22q11 Deletion SyndromeβStudy in a South Indian Population
Indian J Pediatrics., DOI : 10.1007/s12098-015-1954-5.
2015
Pd-Catalyzed Aryl C-H Activation and Tandem ortho-Hydroxylation/Alkoxylation of 2-aryl benzimidazoles: Cytotoxicity and DNA-Binding Studies.
Asian J. Org. Chem. Vol. 3, Pg. 68 ? 76, doi: 10.1002/ajoc.201300214
2014
Design and synthesis of C3-pyrazole/chalcone linked β-carboline hybrids: Antitopoisomerase I, DNA interactive and apoptosis inducing anticancer agents.
Chemmedchem, 9(9), 2084-2098, Doi:10.1002/cmdc.201300406.
2014
Studies on non-covalent interaction of coumarin attached pyrimidine and 1-methyl indole 1,2,3 triazole analogues with intermolecular telomeric G-quadruplex DNA using ESI-MS and spectroscopy
Nucleosides, Nucleotides and Nucleic Acids,Vol. No. 33 and Page No. 489-506.
2014
Synthesis of β-carboline-benzimidazole conjugates using lanthanum nitrate as a catalyst and their biological evaluation
Organic & Biomolecular Chemistry, 12(15), 2370-2373. DOI: 10.1039/c3ob42236d.
2014
Anticancer Activity of Half-Sandwich RhIII and IrIII Metalla-Prisms Containing Lipophilic Side Chains.
Chempluschem DOI: 10.1002/cplu.201300425. Vol. 79, Pages.610-118.
2014
Incidence of Bcr-Abl kinase domain mutations in imatinib refractory chronic myeloid leukemia patients from South India.
2014
Exploiting Natural Products to Build Metalla Assemblies :The Anticancer Activity of Embelin-Derived Rh(III) and Ir(III)Metalla -Rectangles.
Molecules 19, 6031 -6046. doi:10.3390/molecules19056031.
2014
Antiproliferative activities of trithiolato-bridged dinuclear arene osmium complexes.
Inorganica Chimica Acta (ICA). Vol.423, Pg.31-35. http://dx.doi.org/10.1016/j.ica.2014.07.050
2014
Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) 5 alterations to colorectal cancer susceptibility : a case-control study.
Tumor Biology. DOI 10.1007/s13277-014-2505-9
2014
Production of melanin pigment from Pseudomonas stutzeri isolated from red seaweed Hypnea musciformis.
Letters in Applied Microbiology, doi:10.1111/lam.12111.
2013
Phenyl-1,2,3-triazole thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3\'-Azido deoxythymidine.
PLoS ONE 8(8): e70798. doi:10.1371/journal.pone.0070798.
2013
Copper oxide Nanoparticles Supported on Graphene oxide Catalyzed S-Arylation: An Efficient and Ligand free Synthesis of Aryl Sulfides.
Advanced Synthesis and Catalysis, doi: 10.1002/adsc.201300416
2013
Bcl-2 Promoter Sequence G-Quadruplex Interactions with three Planar and Non-planar Cationic Porphyrins: TMPyP4, TMPyP3, and TMPyP2
PLoS ONE 8(8): e72462. doi:10.1371/journal.pone.0072462.
2013
Biological Studies of Chalcogenolato-Bridged Dinuclear Half-Sandwich Complexes.
Inorg. Chem., 52 (23), 13663?13673. doi: 10.1021/ic4022307.
2013
Genetic variants of thiopurine and folate metabolic pathways determine 6-MP mediated hematological toxicity in childhood ALL.
Future Medicine-Pharmacogenomics:13(9),1001-1008.
2012
Interaction of Pyrrolobenzodiazepine (PBD) Ligands with Parallel Intermolecular G-Quadruplex Complex Using Spectroscopy and ESI-MS.
PLoS ONE, 2012, 7 (4) e35920.doi:10.1371 /journal.pone.0035920.
2012
Epistatic interactions between Thiopurine methyltransferase (TPMT) and Inosine triphosphate pyrophosphatase (ITPA) variations determine the 6-Mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia.
European Journal of Clinical Pharmacology. 68:379. doi: 10.1007/s00228-011-1133-1.
2011
Synthesis of Readily Accessible Triazole Linked Dimer Deoxynucleoside Phosphoramidite for Solid Phase Oligonucleotide Synthesis.
Synthesis. 21:3710-3714.
2010
Studies on the site and mode of TMPyP4 interactions with Bcl-2 Promoter Sequence G-quadruplexes.
Biophys J. 98 (11): 2628-2633.
2010
Influence of fermentation metabolites on redox potential in anaerobic digestion of proteinaceous solid wastes by Synergistes sp.
Engineering in Life Sciences. 10(4):1-6.
2010
Effect of ionic strength on porphyrin drugs interaction with quadruplex DNA formed by the promoter region of C-myc and Bcl2 oncogenes.
Journal of Nucleic Acids. Article ID 146418,9 pages,2010. doi:10.4061/2010/146418.
2010
In situ immobilization of acid protease on mesoporous activated carbon packed column for the production of protein hydrolysates.
Bioresource Technology.101(4): 1377-1379.
2010
Characterization of an alkaline active - thiol forming extracellular serine keratinase by the newly isolated Bacillus pumilus.
Journal of Applied Microbiology, 104: 411-419.doi:10.1111 /j.1365-2672.2007. 03564. X
2008
Purification of extracellular acid protease and analysis of fermentation metabolites by Synergistes sp. utilizing proteinaceous solid waste from tanneries.
Bioresource Technology, 99: 2364-2372.
2008
Noncovalent Interaction of G-Quadruplex DNA with Acridine at low concentration monitored by MALDI-TOF Mass Spectrometry.
Nucleosides, Nucleotides and Nucleic Acids., 26: 303-315.
2007
Was elusive carnivore a panther? DNA typing of faeces reveals the mystery.
Forensic Science International. 137 : 16?20.
2003
Halomonas glacieisp. nov. isolated from fast ice of Adelie Land, Antarctica.
Extremophiles. 7: 55?61. doi: 10.1007/s00792-002-0295-2
2003
https://www.ccmb.res.in/People/Research-Group/N-Nagesh#:~:text=AcomparativestudyontheinteractionofacridineandsyntheticbisacridinewithGquadruplexstructure.
J. Biochem. Biophys. Methods, 57:65 ?74.
2003
A Comparative study on removal of chromium from water effluents by reduction and adsorption over different carbon materials.
Indian J Environmental Protection, 22(11), 1221-1225.
2002
Genetic Locus Encoding Functions Involved in Biosynthesis and Outer Membrane Localization of Xanthomonadin in Xanthomonas oryzae pv. Oryzae.
Journal of Bacteriology. 184(13):3539?3548.
2002
A useful method for the synthesis of 8 azidoguanosine tri- and tetraphosphate: important substrates for many enzymatic reaction
J. Biochem. Biophys. Methods.35: 61?66.
1997
Ammonium ion at low concentration stabilizes the G-quadruplex formation by telomeric sequence.
J. Biochem. Biophys. Methods, 30:1-8.
1995
Terbium( III )-Induced Fluorescence of Four-Stranded G4-DNA.
Biopolymers. 32: 1421-1424.
1992
A study on removal of chromium by adsorption on bituminous coal from synthetic effluents.
Indian J Environmental Health, 31(4),304-308.
1989
A study on removal of chromium by adsorption on activated charcoal from synthetic effluents.
Indian J Environmental Proection, 9(4): 301-303.
1989
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